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Server Applications:

  1. Web server with partial caching
    • A caching proxy
    • memCached
    • Relational databases
    • Indexed data, like lucene, or some kind of hash-table
    • virtualized servers

Scientific Applications:

  1. MatLab et al.
    • custom (or not) machine learning
    • various things like protein folding.
    • more stuff I'm not qualified to actually list

Media Applications:

  1. broadcast ready video stuff using uncompressed feeds
    • general video editiing, with scrubbing etc would benefit
    • graphic design. The less files you must close the more you can work on.
    • even music production can benefit, say you're working with 256 tracks and a lot of virtual instruments and effects patches, they all maintain state and buffers.

Engineering Applications

  1. Basically any CAD
  2. A lot of simulations that are updated to work with huge datasets.