I have a 2TB HDD formatted with 2 partitions, 1TB each. One partition is for storage the other one is used for Windows 7 backup. The HDD is a Seagate Barracuda, originally it was an external USB hard drive but I put it inside the system for performance reasons.
The problem is that the systems freezes for few minutes when the computer is inactive for long time. I have disabled "Turn off disk after", "Sleep" or "Hibernate" from power options but still have the same problem.
The system works fine when I disconnect this drive.
I have 3 others hard disks on the system (older than this one) and the system is working just fine when this drive is removed.