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I am using Fedora 12 and VirtualBox 3.1.2. My guest OS is Windows XP. How to add a serial port which will be 'physically' connected to /dev/ttyUSB0?

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This is all set out in the VirtualBox documentation. Particularly online or in the pdf. Essentially run VirtualBox and go,

(VM name) > Settings > Serial Ports > Enable port > connect to device

And add the name of your device. Be careful about file permissions.

If you're running headless, I think you can do it through VBoxManage modifyvm.

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