System: Dell M6800 laptop with the AMD M6100GL Firepro GPU. Windows 8.1
System is docked to the Dell eDock (or whatever it is called) and I am running 4 monitors. 1 is via a USB GPU *(26" 1920x1200) 1 is via the DVI-2 on the docking station (26" 1920x1200) 1 is via the VGA out on the docking (1680x1050) 1 is via the D-port (40" 3480x2160).
Symptom: On a semi-regular basis the screen would all go black as if the GPU was rebooting - causing all my Windows to arrange etc as the monitors slowly sprung back into life. If playing a game full screen on the 40" it caused all end of havoc.