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One day instead of connecting to the database my SQL Server Management gave me the following error: "Data Source name not found & no default driver found"

Note it had been working for several years before this, all that had changed was an upgrade to Office (97 ->2000) and the monthly Windows patches.

I tried rebooting, re-installing both the SQL Server 2000 and 2005 clients on the machine but no joy. I can access the database(s) from other machines.

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Just to save anyone else who may have had this (it took me a full day to work it out), it turned out to be a registry problem:

Several keys were missing from the following registry path, I exported the key from another machine and it's all working now.

HKEY_LOCAL_MACHINE\SOFTWARE\ODBC\ODBCINST.INI

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Sorry meant to post this on Server Fault, which I now have - it can be closed here if it's too off topic. –  alimack Feb 16 '10 at 11:03

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