If you are asking - can I do redundancy where you can recover from a drive crash, then there are two answers.
First would be mirror. Two drives acting as one drive. You lose half your drive space, but if one drive crashes, hopefully the other is still okay. Also called Raid 1
Second would be raid 5. Three or more drives acting as one drive. You lose one drive as a error correcting drive. One drive crashes, the others still can compensate.
There are more exotic answers like Raid 10, Raid 01... Not practical for home use.
There is also the special raid type that I believe Drobo uses where they use a methodd that takes about a third of your space, but can recover from any one drive going bad and if you designate a file as critical, makes sure to keep that file on several drives at once.