I have recently upgraded from karmic to lucid (plain ubuntu using gnome).
Everything worked fine, but the characters now aren't anti-aliased any more, as you can appreciate from the screenshot:

This is what I tried to fix the situation, unluckily without succeeding:
- Used the regular option pane from System->Preference->Appearance->Font (smoothing, hinting...)
- Edited the
.fonts.conffile - Disinstalling (and then re-installing) the
mstcorefontpackage - Changing the default
Sansfont to a font of my liking (e.g.Tahoma) from the abovementioned Appearance options
My ubuntu installation is quite standard, with the typical add-ons one might wish for usability. I used the ubuntu start script to make a few tweaks.
fonts.confor just the one in your user's home directory? – Just Jake Mar 29 '11 at 21:09