When I rebuild my desktop, I'm thinking of using server hardware instead of desktop hardware. I want to do this so I can easily add a lot of ECC memory (~20GB), and possibly more than one processor. I know that video hardware could be a problem, especially because I use 4 monitors. I should be fine with this, as long as I have two pci-e channels.
Are there any downsides to doing this? Anything I'm not seeing?