I am an avid fan of Opera, and have been for a number of years. Despite its bad rap, it is a very solidly built browser that has phenomenal standards support.
A some of the sites that I use have started moving from Flash (or custom plugins) to Silverlight. One of the most notable is NetFlix Instant Watch. In some cases, Silverlight works perfectly in Opera. However, in cases such as with Netflix Instant Watch, opera has some trouble loading Silverlight.