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Before I shut down my computer last night everything worked fine. This morning I rebooted and I started getting the error message below when I tried to start debugging my web application:

alt text

What would cause this to suddenly break? How do I fix it?

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Look here, it worked for me:… – user134813 May 17 '12 at 21:29
up vote 1 down vote accepted

Check against this Microsoft Support article:
Error: Unable to Start Debugging on the Web Server

This might also be useful:
Unable to start debugging on the web server

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Kill msvsmon.exe process and restart Visual Studio, It works for me

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