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I've tried the "High Contrast" feature, it doesn't quite do what I want.

MacOS will inverse the color of every pixel -- I think their graphics card does some final rendering on the entire screen, treating it as one large image.

"High Contrast", in 'contrast' (har har), is changing font settings, font color settings, etc.

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You can use the Magnifier in Windows 7. Unlike the one in Vista, it doesn't use a window.
Select "Turn on color inversion" in the options and it will invert the screen colors only.

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Doesn't quite do what I want. I want my entire screen inverted, so I can use it. (Easy way to get white-on-black text in my windows) – user35997 Aug 12 '10 at 2:07
But that's exactly what it does in Windows 7: – Tamschi Aug 12 '10 at 9:07
That's neat...but is there any way to hide the magnifier interface? – Shinrai Aug 12 '10 at 14:27
Yes, I must be missing something. When I run magnifier, a new window appears, (a view port into my current desktop). Only that view port is color-inverted. And I can't actually interact with its contents. What I want is (1) no view port at all, (2) my entire desktop color-inverted, (3) ability to interact with the desktop as usual. Exactly what the video had. What am I missing? – user35997 Aug 12 '10 at 16:53
Okay, much better solution: there's a "diagnose Aero problems" command you can find from your Run menu (search for it). Turns out that Aero was turning itself off (silently!) because I had a USB video card whose max color setting was 16 bits -- less than the 32 bits required for Aero to run. – user35997 Aug 13 '10 at 23:11

If someone ever find this thread, looking for inverting their screen colors, they might be glad to know I created a little program which do exactly that :)

It's called NegativeScreen and it's a simple but complete program written in C# (sources open)

You can try it out here.

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This would be even better if it didn't need Windows Aero, but that would probably add 900% more work to make 1% of the users happier. :) – Gordon Gustafson Oct 20 '13 at 23:21
I find that NegativeScreen is better for the 2 following reasons. It doesn't lag my mouse like the Magnifier does. It doesn't override shortcuts that I use in other applications. – Simon LG Jan 9 '14 at 15:29
An excellent solution. It's even possible to fine tune by the config file for inverse video with low blue light, which is my preference. – Sam Watkins Nov 17 '15 at 12:59

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