As far as I know, In-File delta feature is mostly used by Online-Backup software.
Using Acronis for exchange here too, but being it incremental or differential, it backups the entire file, not just the changed deltas. I still prefer it to any other backup software and if it comes to off-site backups ... I just make a copy of the backups on a removable and move it off-site.
As far as data size is concerned ... the in-file delta backup capable soft does make sense. And I'd very much consider giving some of them a try .. IF I EVER manage to find one which allows me to do my own backups to my own media ... and NOT off-site/online for a monthly fee.
Eventually I can see Acronis implementing this feature though, and I will be the first to pay for it (a one time charge ... rather than a never ending recurring monthly fee).
CrashPlan doesn't support in-file delta incremental backups either ... it only does the standard incremental and differential (and obviously full), features for which .. I am also perfectly happy with Acronis.