can/should I run a disk defrag software on a raid 0 set up?

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If you are using Windows Vista, Windows 7 or Windows 2008/R2, it possibly already does it in the background.

Personally, I would and there shouldn't be any more risk compared to doing it on a regular hard drive.

However, take a look first at the RAID driver/software (if it comes with any) - usually only on high-end hardware raid solutions, see if it has a defrag utility/feature built in.

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It is possible to do so, there isn't anything preventing it. Should you? Well, that's part of the greater Should You Defrag At All debate.

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