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I want to use iptables configuration on my Ubuntu 10.0.4 desktop, however I read that Network Manager and iptables have some conflicts. Should I uninstall NetworkManager? If yes, how?

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There is no problem using iptables with NetworkManager as long as the rules refer to local interfaces (or nothing local at all) instead of local IP addresses.

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well the rules might refer to local IP addresses, for example port forwarding rule from universe to lan PC. – Pablo Sep 4 '10 at 15:16

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