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I wonder what are the things i should clear using CCleaner for best performance. I see that some of the items are cache files eg. Thumbnail cache, DNS cache. will removing them have any negative performance impact?

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I generally avoid messing with the Registry, and just go with temporary files. Deleting caches is not always advisable because Windows will just rebuild them. Your mileage may vary. – Randolph West Oct 2 '10 at 16:26
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The CCleaner Documentation has information on all of their cleaning rules.

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These are the options that I select while using CCleaner. That way I get rid of the junk, while not wiping out my browser history and other details.

CCleaner CCleaner2

CCleaner3

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