I have a PC with different network adapters that provides different internet connections.

How can I setup Firefox (or another browser) to access certain site using one network adapter and other site using another adapter?

Or more in general, how can I force a software application to use a network connection and another software to use another connection?

My OS is Windows XP.

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Doing exactly what you ask is probably not possible. But it may be possible to fulfill your underlying requirement in a different way (perhaps using a proxy or changing your routing configuration). So what are you trying to do? You may also be interested in a somewhat similar question on Linux: bind software to different network interfaces, 2 network interfaces connected to internet. Choose the one to use according to the domain name. – Gilles Oct 27 '10 at 23:05
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In general, it is the operating system, not the application, that decides which network adapter to use, based on target IP-addresses.

If you can arrange that the different adapters are on different subnets, you can set up static routes for the IP-addresses of the websites.

I guess most PCs have their IP-addresses allocated by the local router. These can be configured so that a multi-homed PC gets different subnets for different interfaces.

   ISP1........Router1----------PC----------Router2........ISP2
                       subnet1     subnet2
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