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is there a difference between these two shortcuts on most browsers?

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My completely unresearched educated guess is that Ctrl+F5 generally refreshes the page without using cache while Ctrl+R or plain F5 refreshes the page using cache as normal. I also think this question belongs on Superuser. – MooGoo Oct 30 '10 at 20:42
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Ctrl+F5 does indeed do a force cache purge for that page, while Ctrl+R does not.

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so it is same as F5? – Infestor Oct 30 '10 at 21:05
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@Infestor, in Firefox F5 and Ctrl-R are the same. Ctrl-F5 and Ctrl-Shift-R are the same too. Of course, that's only one out of many browsers. – Arjan Oct 30 '10 at 22:59
(As an aside: using F5/Ctrl-R might make a browser still ask the server if the content has changed by using If-Modified-Since headers, hence still leaving it up to the server to serve new content or not. Hitting Ctrl-L to get to the location bar and pressing Return, or selecting a bookmark makes most browsers rely on their cache without asking the server about any changes.) – Arjan Oct 30 '10 at 23:08
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