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On XP, in TweakUI I set the mouse wheel to scroll by 1 line rather than the default 3. When I reboot it's always set back to 3. It's a laptop with a generic Dell mouse and I can't see any specific mouse service running in Process Explorer. It happens when docked or undocked. Any ideas how to make the setting stick?

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It seems that this is a known issue with Dell (and Microsoft) mice: – user3463 Jul 28 '12 at 5:04

I had this problem with my HP laptop. Try to install the latest driver from Dell.

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