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If I disable it on my computer will I lose anything?

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IPSec is used to establish a virtual private network (VPN). If you don't use any VPNs, I doubt disabling it will hurt anything.

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IPsec is only available for use with IPv6. IPv4 doesn't even recognize that it exists. – Deoetpatria Aug 17 '11 at 9:51
@Deoetpatria - There are many uses of IPSec, I run IPv4 IPSec tunnels across my networks. – William Hilsum Feb 17 '13 at 20:58
@Deoetpatria That is patently false. IPsec works just as well with IPv4. RFC 6071, IP Security (IPsec) and Internet Key Exchange (IKE) Document Roadmap, states in its introduction that "IPsec and IKE can be used in conjunction with both IPv4 and IPv6." It also works with many other protocols, see section 8 of that RFC, "Other Protocols That Use IPsec/IKE", which has 10 subsections. – Jeremy W. Sherman Feb 18 '13 at 15:56

Unless you (or someone administrating your computer) have configured IPSec to communicate securely with other hosts, disabling it won't hurt.

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