If I disable it on my computer will I lose anything?

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IPSec is used to establish a virtual private network (VPN). If you don't use any VPNs, I doubt disabling it will hurt anything.

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IPsec is only available for use with IPv6. IPv4 doesn't even recognize that it exists. – Deoetpatria Aug 17 '11 at 9:51
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Unless you (or someone administrating your computer) have configured IPSec to communicate securely with other hosts, disabling it won't hurt.

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