I am researching for a project what would require 20 monitors to be driven from (ideally) a single Mac Pro. The only solutions i have seen and are familiar with are geared towards 2-4 monitors from a single machine. Is this even possible?
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What you are looking for is a Video Distribution Amplifier.
I believe a DVI splitter like this can be daisy-chained.
There are HDMI splitters too. This one is nice because the signal can be transmitted over CAT 5/6 Ethernet cables. Not sure if it's cascade-able though. Here's a 3x8 HDMI switch splitter which specifically states it can cascade signals, so you just daisy-chain them together. You'll need three. :)
EDIT: A little more googling, found this 1:10 HDMI VDA. You only need two of those!
I hope you have a lot of money for this project. ;-)
Not sure if this is your solution but LG has a network monitor solution. This allows for a single PC to be shared by up to 11 users at the same time.
I haven't tried this out myself but I have seen it in action at a computer showroom dealing in LG products. So if you need different content on your monitors, this should work. This technology is called Desktop Virtualization.