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I am specifically creating a VirtualBox environment to deal with malware files. When I connect my USB pen-drive, I want it to be opened in the virtual environment, but the main environment i.e., Windows 7 should not be able to recognize it.

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up vote 3 down vote accepted

You'll have to set up a USB Filter for this.

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It recognizes with the vendor name or the port number? – RPK Dec 31 '10 at 18:26
You can define your own settings based on device label string, serial no. and more. Please read the article. – John T Dec 31 '10 at 18:30

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