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Is using 2x2gb DDR3 in dual-channel faster than using a single 4gb DDR memory stick on a 4-slot motherboard?

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You might find Performance of Multiple RAM Sticks Compared to Single Sticks interesting as well, althought it takes a different slant on this topic. – DMA57361 Jan 21 '11 at 12:34

Tom's Hardware tested this and the results were that the difference is negligible:

Difference between dual-channel and single-channel

The main reason for this is probably that even though there are two channels, they still have to interact with the CPU using the same bus which is a pretty huge slowdown for lots of things.

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