I unfortunately have to use Adobe Reader X on my Mac.
In the past, I could set Preview as the default PDF viewer in Safari, but with Adobe Reader X, that option is disabled!

I already know that I can delete Adobe’s plug-in, but I’m pretty sure it will just come back the next time the damn thing auto-updates.
The “right” way is to change that setting, which (at least in previous versions) maintained the setting through updates. How do I do it?