Compressed air is handy for connectors and hard-to-reach parts (eg: inside the PSU), but for general cleaning, get yourself two natural bristle/wooden handled paintbrushes (all natural materials and no plastics to build up static) - a 1" and a 2" one and use these to gently brush out the insides.
To comment on a few other answers, based on industry best practice:
1) Vacuum cleaners - not unless they are specifically designed for the job due to the static electricity problem mentioned.
2) Airlines - be careful with the ones designed to operate tools as their airflow might contain oil vapour to lubricate the tools (using one of these: http://www.about-air-compressors.com/air-line-lubricators.html), so you will effectively be spraying a thin film of oil into connectors, onto components and leaving a dust trapping layer everywhere. Also, as mentioned, the air pressure can be high enough to damage components.