I am having some problems with mouse clicking in Windows 7 64 bit. Certain programs (e.g. Visual Studio) don't respond to mouse click consistently. It's a very odd problem--certain types of mouse clicks, like switching between open files by clicking on the tabs up top, work perfectly every time. Other types of clicks, like clicking the left-sides tabs in the property page, require multiple clicks to register. Dialog boxes from many programs also seem to have to same problem pretty consistently. Oddly, even when the click fails, the screen seems to indicate visually that the click worked, but the intended action does not occur.
I have updated every driver I can think of to the latest version (both monitors, mouse, graphics card), and nothing has solved the problem.
I did not try different hardware, as (like I said) SOME applications or situations have very consistent click behavior.