I like to use the keyboard exclusively without touching the mouse. How can I end a Skype call without touching the mouse?
On the latest Skype version (5+), you can go to Options > Advanced > Hotkeys. Check off the "Enable Keyboard Shortcuts" box, then check "Hang up", and set it to the key you want.
This is for Windows. I am not sure the status of the Linux or Mac ones, but I believe they should have similar function as the Windows version has had this a long time.