The use case where I see this the most is when I want to open the "Spaces" app from Spotlight. I would love to minimize the keys it takes to do this, but because other application exist with similar name (Disk Space Cleanup Management) I need to type Spaces all the way out before it shows up in the result set.
It is the only application that I launch from Spotlight that starts with "S" but Spotlight seems unable to learn this. Any way to prevent other apps from getting top billing (System Preferences, Spider, Spin Control...)
