I have a mouse with three buttons but no wheel.

In OS X, is there any way (perhaps with addon software) that would allow me to use my third button for scrolling by holding it and moving the mouse?

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Smart Scroll does what you are looking for. It doesn't work in all software (Terminal being the most notable exception -- although iTerm does support it) but I swear by it. It has a free trial.

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It depends on the software - for example, Firefox supports it, while Google Chrome does not.

Currently there is no software to enable such feature system-wide in OS X, sadly.

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