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I just installed Microsoft Office 2010 x64
But when I want to open it this error appears :

Windows Cannot find 'C:\Program Files\Microsoft Office\Office14\WINWORD.exe'. Make sure you typed the name correctly, and try again.

I'm dead sure the file exist.
How can I fix it?

P.S:
-I recently edit the registry manually, before installing MS Office 2010
-I deleted some registry keys (20 to 25 reg keys).
-In addition, in opening some of other programs the same error has occurred.

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You're sure you have 64-bit Office installed? It's not at C:\Program Files (x86)\ ? –  Bacon Bits Jun 30 '11 at 17:28
1  
Incase no one has told ya, it is a good idea to backup the registry before messing with it. Regedit has an export function. Takes two seconds. –  surfasb Jul 1 '11 at 5:13

3 Answers 3

Based on your comments, especially this:

I went to C:\Program Files\Microsoft Office\Office14, but when I execute Winword.exe the error occur

And this:

-I recently edit the registry manually, before installing MS Office 2010

-I deleted some registry keys (20 to 25 reg keys).

-In addition, in opening some of other programs the same error has occurred.

I'd venture to guess you hosed something up in your registry, especially if the other programs worked before you started editing. If that's the case, you'll have to restore from a System Restore point (assuming you haven't disabled it) to a time before you made the edits, and see if that helps.

Since you commented that you don't have system restore enabled, then it sounds like your best course of action is to back up and reinstall Windows.

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Unfortunately I disabled System Restore :-( –  Mohammad Jun 30 '11 at 17:49
    
Well, sounds like you're looking at backing up your data and reinstalling. Editing the registry can be a dangerous thing, and from the sounds of it, you're finding that out firsthand. –  Xanny Jun 30 '11 at 17:53
    
The things people will do to "optimize" their system . . . –  surfasb Jul 1 '11 at 5:16

I would try making a new shortcut, and seeing if that fixes it.

The location of the current default shortcut in the Start Menu is here:

C:\ProgramData\Microsoft\Windows\Start Menu\Programs\Microsoft Office\Microsoft Word 2010.lnk

I would also test by going to that directory, C:\Program Files\Microsoft Office\Office14\, and executing Winword.exe directly.

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I went to C:\Program Files\Microsoft Office\Office14`, but when I execute Winword.exe` the error occur –  Mohammad Jun 30 '11 at 17:37
    
Was there a previous version of Office on the computer? –  KCotreau Jun 30 '11 at 17:38
    
@: KCotreau : NO –  Mohammad Jun 30 '11 at 17:49
    
OK, last question what, in general did you delete from the registry, and where was it? In HKLM or HKCU? If in HKLM, you might just be out of luck, but if in HKCU, I would create a new user and try that one, and if it works, I would copy the profile data off, and make a new profile. –  KCotreau Jun 30 '11 at 17:57
    
Actually, there may be one more tool you can try to fix broken registry stuff: The Microsoft Readiness Tool. microsoft.com/download/en/… It can take up to two hours to run. –  KCotreau Jun 30 '11 at 17:59
up vote 0 down vote accepted

Eventually I reinstall Windows and the problem has been solved.

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