I had that issue a while back on another PC, setpoint works fine on my current notebook however.
What I did, uninstall setpoint and installed Microsofts Intellipoint software, and installed it, found a compatible MS mouse model that worked with my Logitech buttons and functions and selected that MS model during Install during setup of the software. I think you can change the model after install if you did not select one that did not quite match during setup.
Then to further customize my buttons, I installed X-Mouse
x-mouse will not work with generic windows mouse driver, as it only intercepts the mouse click, and generic mouse driver will not have drivers for anything other than right and left click, the reason I used intellipoint.
I have not used intellipoint in a while, the older versions did not care what brand of mouse you had, if the newer versions do, look for an older version of intellipoint.