The apache2 package is used to select the other packages you need as part of the Apache installation. apache2-mpm-prefork defines which 'processing model' will be used (prefork in this case). The other options are apache2-mpm-event, apache2-mpm-itk and apache2-mpm-worker.
One is not necessarily more (or less) secure than another, as the differences between each are in how they handle setting up to receive new requests - MPM == Multi-Processing Module.
For most uses the apache2-mpm-worker MPM is appropriate.
If you use aptitude on your Debian system, when you select the apache2 package, apache2-mpm-worker, apache2-utils and apache2.2-common will be selected for you automatically (along with any other support packages which are not already installed on your system). Similarly:
apt-get install apache2
Will install apache2, apache2-mpm-worker, apache2-utils and apache2.2-common.