I work for a university. Some faculty distribute their lectures as Powerpoint slideshows with embedded audio. The audio works fine for most students, but a few are having issues. All the students have Powerpoint 2010.
If I extract the audio from the Powerpoint slide (by changing it to a zipfile), the audio clips play just fine on the student's computer. This ensures it is not a problem with the audio being embedded improperly or using a codec they do not have available.