I have Dell Latitude E6500 with Nvidia Quadro 160M and I just bought two DELL U2410 external monitors . I connected one to the DisplayPort and the other to VGA. After a while of using Skype, Outlook, and Firefox Windows 7 x64 slows to crawl. I've been trying everything I can think of, even connecting only one of the monitors (They have a 1920x1200 native resolution) but to no avail. Finally, I disconnected both and after 15 reboots everything is running smoothly again.
Before I got the new Dell monitors I was using an old 19" Samsung 1600x1050 through VGA without a problem. I've never heard of monitors doing this to a system before (I've been trying to pinpoint the issue for some hours now).
Anybody had something similar? I've newest nvidia drivers, fully updated windows 7 with Intel SSD drive. I was even running quick tests/smart tests on the drive but it was passing without problems.
EDIT:
CPU is P9700 @ 2.8Ghz and 4GB of RAM with Intel SSD and Nvidia Quadro 160M. The laptop runs natively with 1920x1080p on my main laptop monitor.
After the issue I reported above: I've disconnected VGA monitor and only 1 monitor was connected with Laptop's lid closed. After a reboot the laptop ran at a crawl straight from POST. A hard shut down with button held for 5 secs was the only thing that restored normal operation... For now...