There is a command-line switch for Chrome for setting Disk cache size and location.
Mine looks like this:
If you want to have these settings all-the-time, you need to modify ALL your icons, and your registry.
I have modified all my icons. And my registry.
However, my registry reverts all the time. How can I protect my registry from this?
The registry modification looks like this (exported it from my registry; .reg file):
Windows Registry Editor Version 5.00
[HKEY_CLASSES_ROOT\ChromeHTML\shell\open\command] @="\"C:\Users\username\AppData\Local\Google\Chrome\Application\chrome.exe\" --disk-cache-dir=\"C:\0\cache\" --disk-cache-size=1073741824 -- \"%1\""