I have recently got my new computer and I have a problem with "Lucida Sans" fonts being too sharp on Google Chrome 12.0.742.122 and Windows 7 Pro (Preloaded with Thinkpad x220).
I don't have this problem on Windows 7 Ultimate with the same Chrome version.
Here is an image that show the problem:

I have tested this on this page. It uses Lucida Sans Typewriter with 12px font size. When I've set 13px font size, the text is more smooth.

Note that ClearType is enabled. Disabling it makes it even worse.
Any ideas how to fix it?