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It seems to be an access right problem. I can't find the solution. I just try to grant full access (administrator) but it doesn't work. enter image description here

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Did you run setup as Administrator? – Andrejs Cainikovs Sep 8 '11 at 19:00
Using Win 7 32 or 64-bit? The install file looks to be for 32-bit. – SgtOJ Sep 8 '11 at 19:01
@Andrejs: Yes, I tried, same problem. $SgtOJ: Win7 32bit. – Emerald214 Sep 8 '11 at 19:12
What is in the path that is specified in the error box? – Andrejs Cainikovs Sep 8 '11 at 19:18
I don't know, I just click "Next" and "Install", perhaps VirtualBox used that path to store temporary files. – Emerald214 Sep 8 '11 at 19:38

Rather late in the day, but it might help someone else

I (just) had this problem - checking the temp folder showed the file was there, but any amount of trying failed. Then I "took ownership" of the temp folder and contents, and everything went fine. Taking ownership comes upon my x64 PC when I right click on a file or folder

Had a sneaky feeling the take ownership option was non standard - this link shows how to get it.

For completeness, here's the registry key which adds that

Windows Registry Editor Version 5.00

@="Take Ownership"

@="cmd.exe /c takeown /f \"%1\" && icacls \"%1\" /grant administrators:F"
"IsolatedCommand"="cmd.exe /c takeown /f \"%1\" && icacls \"%1\" /grant administrators:F"

@="Take Ownership"

@="cmd.exe /c takeown /f \"%1\" /r /d y && icacls \"%1\" /grant administrators:F /t"
"IsolatedCommand"="cmd.exe /c takeown /f \"%1\" /r /d y && icacls \"%1\" /grant administrators:F /t"
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It appears you are running the program directly from the browser. Try saving the file first then right click the file and run as Administrator.

I also notice that the error box is referring to 4.0.8 while you appear to be installing 4.1.2. Hopefully saving this off to a download folder will clear that up.

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No, I downloaded VirtualBox and installed offlinely. The browser in the picture is irrelevant. – Emerald214 Sep 8 '11 at 19:40

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