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I have seen that most of virus , spyware etc changes few registry files which are linked to boot process or which starts when window loads user settings.

Is there any way to lock those files which are linked to start the system like explorer.exe , userinit.exe so that virus at least should not be able to stop the system to start up.

Why did'nt microsoft put those registry file separately so that nothing can touches them

Now my userinit.exe file is affected and its not letting me logn on to computer. I get blank desktop but system loads during safe mode. I have run anti virus bootable cd but still have not found solution

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The registry entries should not be locked, Windows needs access to them also. You are best to back up your data and do a clean install of XP, – Moab Nov 15 '11 at 21:39
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There is a simple locking mechanism: log in as a non-Administrator user. That stops most viruses.

Also, the registry file (actually files) are separate. Doesn't help that much, actually.

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