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Severe RSI is causing me pain each time I click the mouse.

I would like to map the right CMD and OPT (which I never use) to function as left and right mouse button.

How can I accomplish this?

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KeyRemap4MacBook does exactly that. It installs under System Preferences and allows you to remap the right Command button to a left click:

enter image description here

The same is possible for the right option key too. It worked for me on a 2011 MacBook Pro running Snow Leopard—couldn't test it on a "normal" Mac, but it should work regardless of that.

There's an app called BetterTouchTool. In its Preferences, under Keyboard, you can set any keyboard shortcut to map to a primary or secondary click. The problem is that cmd and alt are modifier keys, so they aren't a keyboard shortcut recognized by the app.

Another program called DoubleCommand might be worth mentioning as well, but it does not emulate clicks.

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None of those will make the key bound to a secondary click act like the Windows menu key though. You'll still need to move the cursor before pressing the key. – Lri Nov 21 '11 at 6:16
@Lri I didn't experience any problems with it – what exactly do you mean? – slhck Nov 21 '11 at 8:36
Like you can't use the primary or secondary click keys to perform actions on items focused with the keyboard. – Lri Nov 21 '11 at 8:54
I have never used this functionality in OSX. If I can move the mouse with one hand and click with the other, this is enough. – P i Nov 21 '11 at 10:38
@Pi That should work then, yes. It did for me! – slhck Nov 21 '11 at 11:00
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