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One of my collegues in the company uses a Mac (10.5.8) and recently he loses his keyboard shortcuts (ALT+TAB, ...) and his Spaces after a while. The only way to resolve this is a restart.

It occurs very randomly so I can't give a lot of information about this. Does anyone recognize this problem?

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up vote 1 down vote accepted

It's hard to troubleshoot this, but in the case of any random glitches, your best bet would be to try in a new user account and see if the problem persists there.

If that's the case, I'd just migrate to a new user profile.

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