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How can I lock a particular disk drive (C:, D: or E:) in my computer with passwords? Is this possible in Windows7?

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You can try TrueCrypt, which will encrypt it. Of course, if you lose the password, there is no way to retrieve the info.

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Windows Bit Locker is an option although it is unfortunately not available in all versions of Windows 7, details here:

Windows 7 Bit Locker

(Personally, I would probably use TrueCrypt)

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How about just putting the files on those drives into folders and then setting the permissions so only your user account (with a password nobody else knows) has access?

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