To simplify backups
Use Case 1: Relocating documents to a separate local or NFS partition
Lets say you like to update your Operating System with each new release. A typical backup approach would be to copy your home folder to a separate partition so you can copy the contents back after the install.
What I typically do is symlink the folders I want to keep backed up to the separate partition. To restore the symlinks, I just run a quick bash script to restore the links after the OS install.
I would just call it backing up your data but there's really no additional 'backup' step. The nice part is if you accidentally pull a noob move like 'rm -rf' your filesystem, rm doesn't follow symlinks so you won't lose your files.
Note: I understand that you can change the location of where /home is mounted using /etc/fstab. The reason I don't use that technique is because I only want to selectively link parts of my user files and leave any accumulated junk behind.
Use Case 2: Using a cross-platform partition (the easy way)
The added benefit to using symlinks (soft links) is that they work across different filesystems.
Some of us don't have the luxury (due to business needs) of being able to use Linux as our only OS so we jump back and fourth a lot. To extend Case 1, what I personally do is use a NTFS partition for my user files and symlink out the various config and user files that I want to pull into Linux. That keeps all of my stuff in one place.
Note: If you didn't already know, you can also create symlinks in Windows using the MKLINK command.
Imagine this. You have a Dropbox account that you use in both Linux and Windows. To keep from having to download/sync two copies of the same files it's as easy to use everything across both OSes as symlinking to the Dropbox folder on the NTFS partition from your /home folder.
Note: To auto-mount a NTFS drive (in Debian based distros, not sure about others) you'll have to add an mount point in /etc/fstab with umask=000 for write privileges.
Use Case 3: To support default and custom folder structures simultaneously
Lets say you are a webdeveloper that is in charge of working on multiple websites.
You got your testing server setup properly in:
/opt/lampp
You could try to create one massive configuration that works across all sites but that will become cumbersome to maintain over time as new sites are added. The more sites you add the more out-of-sync the permission settings will be with the production server.
What happens when you want to drop in the production server config to test for security vulnerabilities or to verify that no server-side scripting errors are being displayed to the users. Do you just add another set of exceptions for that? How confident are you that your testing configuration is the same as the one the other developers on the team are using.
Apache specifically is extremely flexible when it comes to configurations but with flexibility comes complexity; and complexity introduces risk when you're writing code for the web.
Fortunately, there's a much simpler approach. Create a bash script for each website with --testing and --production arguments. Then just configure the arguments to drop the proper symlinks into the htdocs and config folders for the specific configuration. The site could be under version control, on a separate partition, or even on a remote share. It doesn't matter, as long as the symlinks point to the right place.