I have a problem with cron on Ubuntu 10.04 and 11.04.
I have typed:
49 22 * * * /usr/bin/transmission-gtk
I have also tried:
sudo /etc/init.d/cron restart pgrep cron
The real problem, I think, is that
but it's an odd thing to do; in your case, you'll probably just get a new instance of the command every time the job runs.
Your question doesn't indicate what the actual problem is. What happens, what did you expect to happen, and how do they differ?
I've cleaned up your question's tags and formatting.
Perhaps you should find a non-interactive BitTorrent client.