On Mac OS X Google Chrome writes it's settings on the file:

~/Library/Application Support/Google/Chrome/Default/Preferences

When updating a setting through the Chrome UI the correct value is written to the file. When updating the value on the file (with Chrome closed), on load Chrome rewrites previous values to this file.

Is there a way to make Chrome not ignore my changes on it? Must I use Google's UI to change preferences?

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I'm having the same problem, and the setting I need to update doesn't have a UI entry. Super frustrating. – Tom Thorogood May 19 at 11:57
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