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It seems Powerpoint is compressing the images in my slides (each slide in my powerpoint is 1 large image). I have turned off image compression in the advanced settings.

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Impossible to say without knowing which version of PowerPoint you have and what method you're using to make the PDF. – Steve Rindsberg Jan 10 '12 at 14:57
Where is the option to turn off image compression? I don't see it in PowerPoint 2007. – Dan Dascalescu Feb 21 '12 at 13:04

If you're using Powerpoint 2007 or 2010 then the max DPI it will save a PDF at is 220, even if image compression is turned off.

You could install PDF printer software like PDFCreator then "print" your presentation, make sure to check the High Quality checkbox. In PDFCreator click Options then Formats -> Compression and change the compression from Automatic to the level of compression you want e.g. JPEG-Minimum. I wouldn't recommend completely turning off compression as this will create a huge PDF document.

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Note that the export bitmap resolution may be increased to a maximum of 300DPI by making the following registry change for the corresponding version of PowerPoint:

2013 : HKEY_CURRENT_USER\Software\Microsoft\Office\15.0\PowerPoint\Options
2010 : HKEY_CURRENT_USER\Software\Microsoft\Office\14.0\PowerPoint\Options
2007 : HKEY_CURRENT_USER\Software\Microsoft\Office\12.0\PowerPoint\Options
2003 : HKEY_CURRENT_USER\Software\Microsoft\Office\11.0\PowerPoint\Options

Add a new DWORD value, ExportBitmapResolution and set it to decimal 300.

Full info from Microsoft at :

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