I have a problem where system sounds work (If I type a non-existant application/file into run, I hear a error sound) and when I test the sound with the Realtek HD Audio Manager, it also works, however applications like Steam, Google Chrome and Skype for example won't work.
Reinstalling the drivers works after reboot, however upon another restart/shutdown it wont work.
Update: It seems that VLC Media Player works, however Google Chrome, Firefox and games don't detect the sound card.

Sounds and Audio devicesit says that none are installed. – Adam543i Jan 23 at 1:56