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Mouse wheels behave just the opposite in Windows and Mac OS X. When playing with a web page, the action that scrolls up in MS Windows actually scrolls down in Mac OS X.

Is setting in either OS possible?

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up vote 1 down vote accepted

Open System Preferences » Mouse on your Mac and remove the first checkbox:

enter image description here

This affects mouse and trackpad alike, if have have both. It's something you were shown when you logged in after Lion installation for the first time.

enter image description here

See this How-To-Geek article to get reverse scrolling in Windows using AutoHotkey.

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what about in MS Windows? – onemach Jan 26 '12 at 7:21
@onemach See that last paragraph with the link to the How-To Geek site. It's not supported by the OS, you need additional software, e.g. AutoHotkey, for it. – Daniel Beck Jan 26 '12 at 7:33

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