[EDIT - to simplify and focus the question]
I want to reduce dependencies on cloud solutions for email, feed reading, backup, file sharing, etc. What desktop apps (or locally-hosted web apps) can best replace gmail, hotmail, carbonite/mozy, dropbox, and google reader?
I don't necessarily need to close online accounts, but just don't want all my data tied up elsewhere. Companies come and go, their owners and privacy policies change, etc.