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I've tried seti@home and folding. But are there any other good ones that might have better luck actually making a difference?

I don't want to contribute to a project that is going to use the results for profit, and set@home is just such a long shot. Folding at home hasn't yet made any discoveries as i know either.

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Maybe WorldCommunityGrid is for you. – Oliver Salzburg♦ Jan 29 '12 at 17:09
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The best ones out there:

F@H is closely related to the Stanford university and WCG hosts projects, which most come from universities, too. They both also have quite a good contact to their users for feedback and wanted changes to their software.

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"Best" according to what metric? – Daniel Beck♦ Jan 29 '12 at 17:17
@DanielBeck To my very own? And in addition to that, community effort, scientific research, technical engineering... F@H is one of the technical most finest multithreading apps out there. – bamboon Jan 29 '12 at 17:27
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The BOINC system has a page of distributed computing projects you can become a member of.

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