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When I attempt to open an excel file from Sharepoint using Google Chrome, I get an error message: that there is an unsupported feature and would I like to open in Excel. If you say yes, then I get another error saying I must have excel and my browser must be configured to open directly from excel in the browser ??? Anyone seen this before ?

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SharePoint version you are using? – Dave M Feb 16 '12 at 15:06

Installing the Chrome extension IE Tab did the job for me.

It has the ability to auto-detect URLs so whenever I browse to our SharePoint it emulates Internet Explorer. Finally I can open Office documents directly from Chrome.

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Note: IE Tab is windows only. – Anna Jan 22 '13 at 18:23

This article provides details on browser support for SharePoint 2010 Browser Support Chrome is now supported. Even some MS browsers have limitations. Firefox is also listed as supported.

There are a number of comments on Chrome on various MS sites and others that some features work but not fully supported. For example Cross Browser suport or MSDN discussion

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There is a glitch in the MS TechNet Browser Support page which does not render the product version selector correctly. A valid URL for the SharePoint 2010 page version is – JohnC Oct 30 '14 at 19:31

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