According to the Chrome Docs, the Ctrl/Shift+F5 keystroke is only supported on Windows.
Is there any keystroke I can do to fully reload a page without the cache on Chrome for Mac?
User reports in Chrome 17 the bug is resolved bug report here in Linux, and the other post of the same request reports that cmd+shift+r forces a reload. I wasn't however able to find a 'from chrome support' response, or a definitive supported example of this in action.
Hope this helps
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Just to be sure I always check 'disable cache' in the developer tools settings(icons bottom right when developer tools is open). That forces to reload the cache all the time when your console is open. When it is closed it uses the cache again.
I find cmd+shift+r not reliable.